Understanding Fentanyl Use
Fentanyl is a synthetic opioid that is 50 to 100 times stronger than morphine. While it has medical uses in controlled settings, illegally manufactured fentanyl is a leading cause of fatal overdoses in the U.S. This page provides vital information about what fentanyl is, how it affects the body, the risks of unintentional exposure, and where to find support.

What Is Fentanyl?
Fentanyl is a powerful synthetic opioid that’s 50 to 100 times stronger than morphine. Originally created for medical use in severe pain and end-of-life care, it’s now a major driver of overdose deaths across the country. Illicit fentanyl is often mixed into other substances — including pills, heroin, and cocaine — without the user knowing. Just a few grains can be lethal. Fentanyl is not like other drugs — it’s faster, more potent, and more unforgiving.
⚠️ Fentanyl Overdose Statistics
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U.S. Fentanyl-Related Deaths (2024)
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Colorado Fentanyl Deaths (2024 est.)
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Estimated CO Deaths
So Far This Year
National projections show approximately 48,743 fentanyl-related deaths in 2024.
Colorado’s estimate stands at around 852 deaths in 2024, based on recent averages.
As of today, over 0 Coloradans are estimated to have died from fentanyl-related overdoses this year.
Dangers of Fentanyl
Fentanyl isn’t just strong — it’s unpredictable. Even tiny amounts can kill, especially when mixed with other drugs. Know the full scope of risks below.

Rapid Respiratory Depression
Fentanyl can slow or stop your breathing within seconds — often before you or others realize what’s happening.

Chest Muscle Rigidity
Known as “wooden chest syndrome,” fentanyl can freeze chest muscles — blocking breathing even faster than typical opioid effects.

Extreme Potency Variability
Every pill or batch can vary 50–100× in strength. You never know how much you’re actually taking.

Hidden in Other Drugs
Fentanyl is often mixed into pills, heroin, meth, and cocaine — and you’d never see it. That’s why “one pill can kill.” :contentReference[oaicite:5]{index=5}

Unforgiving Overdose Risk
Just 2 mg — the size of a few grains of salt — can be lethal. It’s far easier to overdose on fentanyl than other opioids. :contentReference[oaicite:6]{index=6}

Deadly When Combined
Mixing fentanyl with alcohol, benzos, or other depressants increases the odds of fatal respiratory failure — even stronger than fentanyl alone.
Signs of Misuse or Overdose
Extreme Drowsiness or Loss of Consciousness
Unusual fatigue, sudden nodding off, or being unresponsive are red-flag signs that someone may have ingested fentanyl, especially unknowingly.
Slow or Shallow Breathing
Fentanyl suppresses the respiratory system. Breaths may become weak, slow, or stop entirely—a medical emergency requiring immediate intervention.
Pinpoint Pupils
Extremely small (pinpoint) pupils are a classic sign of opioid overdose, especially when paired with slowed breathing or unconsciousness.
Blue or Gray Lips and Fingertips
Lack of oxygen can cause skin discoloration around the lips and nails. This often indicates that breathing has slowed to dangerous levels.
Unusual Behavior or Confusion
Disorientation, confusion, or sudden erratic behavior may suggest fentanyl was ingested or laced into another substance.
Drug Use Followed by Sudden Collapse
If someone uses a substance and collapses within seconds or minutes, fentanyl contamination may be the cause. Call 911 and administer naloxone if available.
Myths & Facts About Fentanyl
Fentanyl is surrounded by misinformation. These common myths can lead to dangerous decisions. Let’s set the record straight with real facts — no fluff.
Risks & Dangers of Fentanyl Use
Fentanyl is involved in the majority of opioid overdose deaths today. Its potency and hidden presence in counterfeit pills make it especially dangerous. Here are the most serious risks associated with fentanyl use—whether intentional or accidental.
Respiratory Failure
Fentanyl can slow or stop breathing within minutes. It’s the leading cause of overdose deaths because it acts quickly and unpredictably.
Cognitive & Emotional Impacts
Chronic fentanyl use may lead to confusion, memory loss, depression, or a flattened emotional response—even outside of overdose risk.
Extremely Small Lethal Dose
As little as 2 milligrams—equal to a few grains of salt—can be fatal, especially when mixed into other drugs without the user knowing.
Injection & Contamination Risks
In illicit markets, fentanyl is often injected or mixed with other unknown substances. This increases the chance of infection, poisoning, or overdose.
Rapid Tolerance & Dependence
Fentanyl causes the body to develop tolerance quickly. This often leads users to take more than intended and experience severe withdrawal if they stop.
High Risk of Accidental Exposure
Many people ingest fentanyl without knowing it—believing they’re taking another drug. Overdoses can happen instantly in these cases.
Where to Get Help
If you’re worried about fentanyl — whether you’ve used it or think someone you care about might — don’t wait for it to get worse. Support is available right now. You don’t have to hit rock bottom to get help.
Frequently Asked Questions
When it comes to fentanyl, staying informed could literally save your life. Here are a few questions people ask when they're trying to make sense of what they're facing.
Can someone overdose without knowing they took fentanyl?
Absolutely. Most people who overdose didn’t mean to take fentanyl — it was hidden in something else. That’s why any street drug can be dangerous now.
What should I do if I think someone is overdosing?
Call 911 immediately. Give naloxone (Narcan) if you have it. Try to keep the person awake and breathing until help arrives. Even if they "wake up," still get medical help.
Is it true that touching fentanyl can kill you?
No. Fentanyl isn’t absorbed through the skin in a dangerous amount. That myth keeps people from helping in emergencies — don’t let it stop you from saving someone.
What if someone doesn’t want help?
You can’t force change, but you can stay present. Offer facts, resources, and support without shame. People come around when they know they’re not alone.
How can I tell if pills are fake or contain fentanyl?
You can’t tell by looking. The only way to check is using fentanyl test strips — they’re legal in many places and easy to use. But no test is 100% guaranteed.
Does outpatient detox work for fentanyl?
Yes. Many people taper off safely using outpatient programs. The key is consistency, support, and monitoring. MAT may also help manage cravings long-term.